A groundbreaking new study has uncovered a surprising potential link between gum disease and Alzheimer’s disease, shedding fresh light on one of the most devastating neurological conditions of our time.
The study was referenced in a press release, sited in the Journal of Periodontology by the American Academy of Periodontology, published January 9, 2024.
In this issue, we will discuss how the bacteria Porphyromonas gingivalis (P gingivalis) — the primary germ behind severe gum disease was found in the brain tissue of deceased individuals diagnosed with Alzheimer’s.
This unexpected discovery points to a possible infectious component in the development of the disease, challenging the long-held view that Alzheimer’s is solely a degenerative brain disorder.
In a series of laboratory experiments, researchers introduced P. gingivalis into the systems of mice. The results were startling: the bacteria not only made its way into the animals’ brains but also triggered the production of amyloid beta — the sticky protein widely known for forming damaging plaques in the brains of Alzheimer’s patients. These findings strengthen a growing belief that Alzheimer’s may, in part, be caused or worsened by microbial infections.
Even more concerning, the study revealed that toxic enzymes produced by P. gingivalis — known as gingipains, were present in the brains of individuals who had not yet been diagnosed with dementia, but whose brain tissue already showed early Alzheimer’s-related changes. This suggests the bacterial invasion could begin years before memory loss and other symptoms appear.
“This is a major step forward in understanding Alzheimer’s disease,” said researchers involved in the study. “If an infection is part of the puzzle, it opens up new avenues for prevention and treatment.”
One of those potential treatments is already under investigation. A pharmaceutical company called Cortexyme has developed an experimental drug known as COR388. In animal studies, this compound has shown promise in reducing both the bacterial infection and the harmful buildup of amyloid beta. Human trials are still ongoing, and scientists caution that more evidence is needed before drawing definitive conclusions.
Nevertheless, the implications of this research are profound. After more than 15 years without a significant breakthrough in dementia treatments, scientists are now increasingly open to exploring alternative explanations — including infectious causes.
In the meantime, experts are urging the public to pay closer attention to their oral hygiene. “Brush, floss, and see your dentist regularly,” researchers advise. “It’s a simple, practical step that may not only protect your teeth but also safeguard your brain.”
As the scientific community continues to explore the possible link between gum disease and Alzheimer’s, this research offers new hope — and a timely reminder that caring for our brains might begin with caring for our mouths.
Dr. Kendal V. O. Major is Founder and CEO of Center for Specialized Dentistry which is a comprehensive family dental practice operating in Nassau. He is the first Bahamian Specialist in gum diseases and dental implants since 1989. He also is a certified Fastbraces provider. His practice is located at 89 Collins Avenue, Nassau at (242) 325-5165 or [email protected].
Link between Gum Disease and your Brain
Important for the elderly in particular to practice good oral hygiene
